Tangled DNA tightens chromosomes
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چکیده
منابع مشابه
Tangled DNA tightens chromosomes
Tangled DNA tightens chromosomes C ramming your vacation wardrobe into your luggage is a breeze compared with the packing job cells perform. Before they can divide, they have to scrunch long DNA molecules into tiny chromosomes. The tangles that form in DNA molecules help this chromosome compression, Kawamura et al. report. The team studies newt chromosomes—they are large and convenient to obser...
متن کاملPacking DNA into chromosomes.
Electron microscopy of HeLa metaphase nucleoids (i.e. whole metaphase cells exposed to 2 M salt and non-ionic detergent) spread by the Kleinschmidt technique, reveals a variety of protein-depleted structures (spreads) derived from chromosomes. Spreads vary in size and shape. At one extreme are oval structures with one or more cores surrounded by a network of supercoiled fibres. These fibres are...
متن کاملDNA tightens the dimeric DNA-binding domain of human papillomavirus E2 protein without changes in volume.
The recognition of palindromic specific DNA sequences by the human papillomavirus (HPV) E2 proteins is responsible for regulation of virus transcription. The dimeric E2 DNA-binding domain of HPV-16 (E2c) dissociates into a partially folded state under high hydrostatic pressure. We show here that pressure-induced monomers of E2c are highly structured, as evidenced by NMR hydrogen-deuterium excha...
متن کاملTangled
A 4-year-old girl presented with 1-year history of fatigue, early satiety, intermittent vomiting, alopecia, pallor, and weight loss without changes in bowel habits or overt gastrointestinal bleeding. Examination revealed thin hair, pale conjunctivae, and mu-cous membranes. Tachycardia and a systolic flow murmur (grade II/VI) were present. Abdomen was nontender, distended, and tympanitic, with h...
متن کاملCompeting chromosomes explain junk DNA.
sciencemag.org SCIENCE Paleoindian, and fishtail points previously provided a roadmap that archaeologists used to trace the spread of Paleoindians throughout the Americas. Such a roadmap is lacking for pre-Clovis sites. Assemblages with distinctive stemmed (“tanged”) chipped-stone projectile points, crescents (lunate-shaped), and leaf-shaped bifaces found in Japan, northeast Asia, western North...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1885iti1